2ck5: Difference between revisions
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== | ==Solution structure of Delta 1-7 aOSK1== | ||
<StructureSection load='2ck5' size='340' side='right'caption='[[2ck5]]' scene=''> | |||
[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[2ck5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CK5 FirstGlance]. <br> | ||
[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [https://pdbe.org/2ck5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ck5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ck5 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref> | |||
[ | |||
==See Also== | |||
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Orthochirus scrobiculosus]] | |||
[[Category: Alphonse S]] | |||
[[Category: Bernard C]] | |||
[[Category: Darbon H]] | |||
[[Category: Mouhat S]] | |||
[[Category: Sabatier JM]] | |||
Latest revision as of 10:49, 23 October 2024
Solution structure of Delta 1-7 aOSK1Solution structure of Delta 1-7 aOSK1
Structural highlights
FunctionKAX37_ORTSC Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1][1] See AlsoReferences
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