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[[Image:2heh.gif|left|200px]]


{{Structure
==Crystal Structure of the KIF2C motor domain==
|PDB= 2heh |SIZE=350|CAPTION= <scene name='initialview01'>2heh</scene>, resolution 2.15&Aring;
<StructureSection load='2heh' size='340' side='right'caption='[[2heh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
<table><tr><td colspan='2'>[[2heh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HEH FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
|GENE= KIF2C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2heh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2heh OCA], [https://pdbe.org/2heh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2heh RCSB], [https://www.ebi.ac.uk/pdbsum/2heh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2heh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KIF2C_HUMAN KIF2C_HUMAN] In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.<ref>PMID:19060894</ref> <ref>PMID:21820309</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/he/2heh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2heh ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of the KIF2C motor domain (CASP Target)'''
==See Also==
 
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
 
== References ==
==About this Structure==
<references/>
2HEH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEH OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Landry, R.]]
[[Category: Landry R]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Shen Y]]
[[Category: Shen, Y.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Wang J]]
[[Category: Wang, J.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: ADP]]
[[Category: MG]]
[[Category: UNX]]
[[Category: adp]]
[[Category: kinesin]]
[[Category: motor domain]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:15:04 2008''

Latest revision as of 12:10, 6 November 2024

Crystal Structure of the KIF2C motor domainCrystal Structure of the KIF2C motor domain

Structural highlights

2heh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KIF2C_HUMAN In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol. 2009 Jan;11(1):27-35. doi: 10.1038/ncb1809. Epub 2008 Dec 7. PMID:19060894 doi:http://dx.doi.org/10.1038/ncb1809
  2. ↑ Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011 Aug 23;21(16):1356-65. doi: 10.1016/j.cub.2011.07.017. Epub 2011 , Aug 4. PMID:21820309 doi:http://dx.doi.org/10.1016/j.cub.2011.07.017

2heh, resolution 2.15Å

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