2d2p: Difference between revisions

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[[Image:2d2p.gif|left|200px]]


{{Structure
==The solution structure of micelle-bound peptide==
|PDB= 2d2p |SIZE=350|CAPTION= <scene name='initialview01'>2d2p</scene>
<StructureSection load='2d2p' size='340' side='right'caption='[[2d2p]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
<table><tr><td colspan='2'>[[2d2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D2P FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2p OCA], [https://pdbe.org/2d2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d2p RCSB], [https://www.ebi.ac.uk/pdbsum/2d2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d2p ProSAT]</span></td></tr>
 
</table>
'''The solution structure of micelle-bound peptide'''
== Function ==
 
[https://www.uniprot.org/uniprot/PACA_HUMAN PACA_HUMAN] Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.<ref>PMID:11175907</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2D2P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2P OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/2d2p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d2p ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hiroaki, H.]]
[[Category: Hiroaki H]]
[[Category: Inooka, H.]]
[[Category: Inooka H]]
[[Category: Jee, J G.]]
[[Category: Jee JG]]
[[Category: Shirakawa, M.]]
[[Category: Shirakawa M]]
[[Category: Tateishi, Y.]]
[[Category: Tateishi Y]]
[[Category: Tochio, H.]]
[[Category: Tochio H]]
[[Category: NH2]]
[[Category: peptide]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:22:35 2008''

Latest revision as of 10:54, 30 October 2024

The solution structure of micelle-bound peptideThe solution structure of micelle-bound peptide

Structural highlights

2d2p is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PACA_HUMAN Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M. Conformation of a peptide ligand bound to its G-protein coupled receptor. Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:11175907 doi:http://dx.doi.org/10.1038/84159
Drag the structure with the mouse to rotate

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OCA
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