2rtz: Difference between revisions

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==Solution structure of MarkTX-7==
==Solution structure of MarkTX-7==
<StructureSection load='2rtz' size='340' side='right' caption='[[2rtz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2rtz' size='340' side='right'caption='[[2rtz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rtz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RTZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RTZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rtz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RTZ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rtz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rtz RCSB], [http://www.ebi.ac.uk/pdbsum/2rtz PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rtz OCA], [https://pdbe.org/2rtz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rtz RCSB], [https://www.ebi.ac.uk/pdbsum/2rtz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rtz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KA261_MESMA KA261_MESMA] Recombinant toxin that reversibly inhibits the potassium current of mKv1.3/KCNA3 channel stably expressed in COS7 cells (IC(50)=150 nM) (PubMed:17624312). Also shows a weak inhibition on Kv1.2/KCNA2, Kv1.3/KCNA3 and TRPV1 channels (PubMed:29483648).<ref>PMID:17624312</ref> <ref>PMID:29483648</ref>
==See Also==
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ohki, S.]]
[[Category: Large Structures]]
[[Category: Umetsu, Y.]]
[[Category: Mesobuthus martensii]]
[[Category: Potassium channel blocker]]
[[Category: Ohki S]]
[[Category: Toxin]]
[[Category: Umetsu Y]]

Latest revision as of 08:30, 17 October 2024

Solution structure of MarkTX-7Solution structure of MarkTX-7

Structural highlights

2rtz is a 1 chain structure with sequence from Mesobuthus martensii. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KA261_MESMA Recombinant toxin that reversibly inhibits the potassium current of mKv1.3/KCNA3 channel stably expressed in COS7 cells (IC(50)=150 nM) (PubMed:17624312). Also shows a weak inhibition on Kv1.2/KCNA2, Kv1.3/KCNA3 and TRPV1 channels (PubMed:29483648).[1] [2]

See Also

References

  1. ↑ Mao X, Cao Z, Yin S, Ma Y, Wu Y, Li W. Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun. 2007 Sep 7;360(4):728-34. PMID:17624312 doi:10.1016/j.bbrc.2007.06.108
  2. ↑ Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub, 2018 Feb 26. PMID:29483648 doi:http://dx.doi.org/10.1038/s41594-018-0033-9
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