Structural highlightsFunctionKA261_MESMA Recombinant toxin that reversibly inhibits the potassium current of mKv1.3/KCNA3 channel stably expressed in COS7 cells (IC(50)=150 nM) (PubMed:17624312). Also shows a weak inhibition on Kv1.2/KCNA2, Kv1.3/KCNA3 and TRPV1 channels (PubMed:29483648).[1] [2]
See AlsoReferences
- ↑ Mao X, Cao Z, Yin S, Ma Y, Wu Y, Li W. Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun. 2007 Sep 7;360(4):728-34. PMID:17624312 doi:10.1016/j.bbrc.2007.06.108
- ↑ Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub, 2018 Feb 26. PMID:29483648 doi:http://dx.doi.org/10.1038/s41594-018-0033-9
| |