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==Three-Dimensional NMR Structure of Rat Islet Amyloid Polypeptide in DPC micelles==
==Three-Dimensional NMR Structure of Rat Islet Amyloid Polypeptide in DPC micelles==
<StructureSection load='2kj7' size='340' side='right' caption='[[2kj7]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kj7' size='340' side='right'caption='[[2kj7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KJ7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KJ7 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Iapp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kj7 OCA], [http://pdbe.org/2kj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kj7 RCSB], [http://www.ebi.ac.uk/pdbsum/2kj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kj7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kj7 OCA], [https://pdbe.org/2kj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kj7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kj7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IAPP_RAT IAPP_RAT]] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism (By similarity).  
[https://www.uniprot.org/uniprot/IAPP_RAT IAPP_RAT] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kj7_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/2kj7_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Brender, J R]]
[[Category: Rattus norvegicus]]
[[Category: Hartman, K]]
[[Category: Brender JR]]
[[Category: Nanga, R]]
[[Category: Hartman K]]
[[Category: Ramamoorthy, A]]
[[Category: Nanga R]]
[[Category: Subramanian, V]]
[[Category: Ramamoorthy A]]
[[Category: Xu, J]]
[[Category: Subramanian V]]
[[Category: Amidation]]
[[Category: Xu J]]
[[Category: Amylin]]
[[Category: Amyloid]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disulfide bond]]
[[Category: Hormone]]
[[Category: Iapp]]
[[Category: Islet amyloid polypeptide]]
[[Category: Rat iapp]]
[[Category: Secreted]]

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