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==THE NMR SOLUTION STRUCTURE OF DENDROTOXIN K FROM THE VENOM OF DENDROASPIS POLYLEPIS POLYLEPIS== | ==THE NMR SOLUTION STRUCTURE OF DENDROTOXIN K FROM THE VENOM OF DENDROASPIS POLYLEPIS POLYLEPIS== | ||
<StructureSection load='1dtk' size='340' side='right'caption='[[1dtk | <StructureSection load='1dtk' size='340' side='right'caption='[[1dtk]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1dtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1dtk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DTK FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dtk OCA], [https://pdbe.org/1dtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dtk RCSB], [https://www.ebi.ac.uk/pdbsum/1dtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dtk ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dtk OCA], [https://pdbe.org/1dtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dtk RCSB], [https://www.ebi.ac.uk/pdbsum/1dtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dtk ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VKTHK_DENPO VKTHK_DENPO] Serine protease inhibitor homolog that selectively blocks voltage-gated potassium channels homooligomer Kv1.1/KCNA1 (EC(50)=0.6 nM) and Kv1.1-containing heterooligomer.<ref>PMID:10429207</ref> <ref>PMID:8612784</ref> <ref>PMID:9134213</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dtk_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dtk_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Dendroaspis polylepis polylepis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Berndt | [[Category: Berndt K]] | ||
[[Category: Guntert | [[Category: Guntert P]] | ||
[[Category: Wuthrich | [[Category: Wuthrich K]] | ||