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| <StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> | | <StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'> |
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| '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref> | | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. |
| | *'''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]). |
| | *'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>. |
| | *'''CED-4''' attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>. lFor details on '''CED-4''' see [[CED-4 Apoptosome]]<ref>PMID:18287011</ref>. <br /> |
| | *'''CED-5''' can accelerate apoptosis in different kinds of cells in response to different stimuli<ref>PMID:26775588</ref>.<br /> |
| | *'''CED-6''' has a role in modulating cellular angiogenesis<ref>PMID:21893193</ref>.<br /> |
| | *For details on '''CED-8''' see [[Apoptosis-inducing factor]]. |
| | *'''CED-9''' prevents cells from undergoing programmed cell death, It is similar to Bcl2<ref>PMID:9384385</ref>.<br /> |
| | *'''CED-10''' regulates apoptosis in malignant T cells<ref>PMID:20854465</ref>.<br /> |
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| | [[Cell death protein 3D structures]] |
| </StructureSection> | | </StructureSection> |
| ==3D structures of cell death protein==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *CED-1
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| **[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
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| **[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br />
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| **[[4zqk]] - hCED-1 extracellular domain (mutant) + hCED-1 ligand<br />
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| **[[2m2d]] - hCED-1 extracellular domain - NMR<br />
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| **[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
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| **[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
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| **[[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br />
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| **[[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br />
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| **[[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br />
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| *CED-2
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| **[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans''
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| *CED-3
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| **[[4m9r]] - nCED-3 - nematode<br />
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| *CED-4
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| **[[2a5y]] - CeCED-4 + CeCED-9 <BR />
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| **[[3lqq]], [[3lqr]] - CeCED-4<BR />
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| **[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
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| **[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
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| **[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
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| **[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
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| **[[3eij]] - hCED-4 residues 157-469<BR />
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| **[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
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| **[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
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| *CED-5
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| **[[1yyb]] - hCED-5 N terminal – NMR<BR />
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| **[[2cru]], [[2k6b]] - hCED-5 – NMR<BR />
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| *CED-6
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| **[[1y1x]] - CED-6 – ''Leishmania major''<br />
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| **[[1hqv]] - mCED-6<br />
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| **[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
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| **[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
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| **[[2zne]] - hCED-6 + CED-6-interacting protein<br />
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| **[[3wxa]] - hCED-6 + SEC31A peptide<br />
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| *CED-8
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| **[[1gv4]] - mCED-8<br />
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| **[[1m6i]] - hCED-8<br />
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| *CED-9
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| **[[1ohu]] – CeCED-9 <BR />
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| **[[1ty4]] - CeCED-9 + programmed CED activator
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| *CED-10
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| **[[3ajm]] - hCED-10 + inositol tetrakisphosphate<br />
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| **[[3l8i]], [[3l8j]] - hCED-10<br />
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| **[[3rqe]], [[3rqf]], [[3rqg]] - hCED-10 + paxillidin peptide<br />
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| **[[3w8h]], [[3w8i]], [[4geh]] - hCED-10 + serine/threonine kinase regulatory domain<br />
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| *CED-HAC-1
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| **[[1vt4]], [[3iz8]] – CED-HAC-1 – ''Drosophila melanogaster''
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |