Cell death protein: Difference between revisions

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{{STRUCTURE_3bik|  PDB=3bik | SIZE=400| SCENE= |right|CAPTION= Human CED-1 extracellular domain.  Programmed cell death protein 1 (green and pink) and programmed cell death 1 ligand 1 (grey) complex with CED-1 ligand 1 and glycerol [[3bik]] }}
<StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain.  Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'>


__NOTOC__
'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis.  
'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes.  For details on CED-4 see [[CED-4 Apoptosome]].
*'''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]).
*'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>.
*'''CED-4''' attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>.  lFor details on '''CED-4''' see [[CED-4 Apoptosome]]<ref>PMID:18287011</ref>. <br />
*'''CED-5''' can accelerate apoptosis in different kinds of cells in response to different stimuli<ref>PMID:26775588</ref>.<br />
*'''CED-6''' has a role in modulating cellular angiogenesis<ref>PMID:21893193</ref>.<br />
*For details on '''CED-8''' see [[Apoptosis-inducing factor]].
*'''CED-9''' prevents cells from undergoing programmed cell death,  It is similar to Bcl2<ref>PMID:9384385</ref>.<br />
*'''CED-10''' regulates apoptosis in malignant T cells<ref>PMID:20854465</ref>.<br />


==3D structures of cell death protein==
[[Cell death protein 3D structures]]
 
</StructureSection>
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
===CED-1===
 
[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br />
[[2m2d]] - hCED-1 extracellular domain - NMR<br />
[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
[[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br />
[[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br />
[[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br />
 
===CED-2===
 
[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans''
 
===CED-3===
 
[[4m9r]] - nCED-3 - nematode<br />
 
===CED-4===
 
[[2a5y]] - CeCED-4 + CeCED-9 <BR />
[[3lqq]], [[3lqr]] - CeCED-4<BR />
[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
[[3eij]] - hCED-4 residues 157-469<BR />
[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
 
===CED-5===
 
[[1yyb]] - hCED-5 N terminal – NMR<BR />
[[2cru]], [[2k6b]] - hCED-5 – NMR<BR />
 
===CED-6===
 
[[1y1x]] - CED-6 – ''Leishmania major''<br />
[[1hqv]] - mCED-6<br />
[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
[[2zne]] - hCED-6 + CED-6-interacting protein<br />
 
===CED-8===
 
[[1gv4]] - mCED-8<br />
[[1m6i]] - hCED-8<br />
 
===CED-9===
 
[[1ohu]] – CeCED-9 <BR />
[[1ty4]] - CeCED-9 + programmed CED activator
 
===CED-10===
 
[[3ajm]] - hCED-10 + inositol tetrakisphosphate<br />
[[3l8i]], [[3l8j]] - hCED-10<br />
[[3rqe]], [[3rqf]], [[3rqg]] - hCED-10 + paxillidin peptide<br />
[[3w8h]], [[3w8i]], [[4geh]] - hCED-10 + serine/threonine kinase regulatory domain<br />
 
===CED-HAC-1===
 
[[1vt4]], [[3iz8]] – CED-HAC-1 – ''Drosophila melanogaster''


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 12:19, 2 June 2024


Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis.

  • CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] CED-1 and CED-L1 complex with glycerol</scene> (3bik).
  • CED-3 is a cysteine protease involved in apoptosis[2].
  • CED-4 attenuates tumorigenesis by translational contro[3]. lFor details on CED-4 see CED-4 Apoptosome[4].
  • CED-5 can accelerate apoptosis in different kinds of cells in response to different stimuli[5].
  • CED-6 has a role in modulating cellular angiogenesis[6].
  • For details on CED-8 see Apoptosis-inducing factor.
  • CED-9 prevents cells from undergoing programmed cell death, It is similar to Bcl2[7].
  • CED-10 regulates apoptosis in malignant T cells[8].

Cell death protein 3D structures

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 1996 May 1;10(9):1073-83. PMID:8654923 doi:10.1101/gad.10.9.1073
  3. ↑ Wang Q, Yang HS. The role of Pdcd4 in tumour suppression and protein translation. Biol Cell. 2018 May 28:10.1111/boc.201800014. PMID:29806708 doi:10.1111/boc.201800014
  4. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
  5. ↑ Malottki K, Popat S, Deeks JJ, Riley RD, Nicholson AG, Billingham L. Problems of variable biomarker evaluation in stratified medicine research--A case study of ERCC1 in non-small-cell lung cancer. Lung Cancer. 2016 Feb;92:1-7. PMID:26775588 doi:10.1016/j.lungcan.2015.11.017
  6. ↑ Rho SB, Song YJ, Lim MC, Lee SH, Kim BR, Park SY. Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2. Cell Signal. 2012 Jan;24(1):131-9. PMID:21893193 doi:10.1016/j.cellsig.2011.08.013
  7. ↑ Xue D, Horvitz HR. Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature. 1997 Nov 20;390(6657):305-8. PMID:9384385 doi:10.1038/36889
  8. ↑ Lauenborg B, Kopp K, Krejsgaard T, Eriksen KW, Geisler C, Dabelsteen S, Gniadecki R, Zhang Q, Wasik MA, Woetmann A, Odum N. Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis. APMIS. 2010 Oct;118(10):719-28. PMID:20854465 doi:10.1111/j.1600-0463.2010.02669.x

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