Cell death protein: Difference between revisions

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Michal Harel, Alexander Berchansky

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-{{STRUCTURE_3bik|  PDB=3bik  | SIZE=400| SCENE= |right|CAPTION= Human CED-1 extracellular domain complex with CED-1 ligand 1 and glycerol [[3bik]] }}
+<StructureSection load='3bik' size='350' side='right' scene='50/507728/Cv/1' caption='Human CED-1 extracellular domain.  Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code [[3bik]])'>
+'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis.
+*'''CED-1''' is a T cell regulator.  CED-1 is expressed on the surface of T cells, B cells and macrophages.  It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis.  CED-1 has 2 ligands: CED-L1 and CED-L2.  Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> CED-1 and CED-L1 complex with glycerol</scene> ([[3bik]]).
+*'''CED-3''' is a cysteine protease involved in apoptosis<ref>PMID:8654923</ref>.
+*'''CED-4''' attenuates tumorigenesis by translational contro<ref>PMID:29806708</ref>.  lFor details on '''CED-4''' see [[CED-4 Apoptosome]]<ref>PMID:18287011</ref>. <br />
+*'''CED-5''' can accelerate apoptosis in different kinds of cells in response to different stimuli<ref>PMID:26775588</ref>.<br />
+*'''CED-6''' has a role in modulating cellular angiogenesis<ref>PMID:21893193</ref>.<br />
+*For details on '''CED-8''' see [[Apoptosis-inducing factor]].
+*'''CED-9''' prevents cells from undergoing programmed cell death,  It is similar to Bcl2<ref>PMID:9384385</ref>.<br />
+*'''CED-10''' regulates apoptosis in malignant T cells<ref>PMID:20854465</ref>.<br />
-'''Cell death proteins''' (CED) are involved in the process of cellular apoptosis.  For details on CED-4 see [[CED-4 Apoptosome]].
+[[Cell death protein 3D structures]]
+</StructureSection>
-==3D structures of cell death protein==
+== References ==
+<references/>
-===CED-1===
+[[Category:Topic Page]]
-[[3rrq]] - hCED-1 extracellular domain – human<BR />
-[[3sbw]] - mCED-1 extracellular domain + CED ligand 1 – mouse<BR />
-[[3rnq]], [[3rnk]], [[3bp5]] - mCED-1 extracellular domain + CED ligand 2<BR />
-[[3bp6]] - mCED-1 extracellular domain (mutant) + CED ligand 2<BR />
-[[1npu]] - mCED-1 extracellular domain (mutant) <BR />
-[[3bik]] - hCED-1 extracellular domain + CED ligand 1
-===CED-2===
-[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans''
-===CED-4===
-[[2a5y]] - CeCED-4 + CeCED-9 <BR />
-[[3lqq]], [[3lqr]] - CeCED-4<BR />
-[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
-[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
-[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
-[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
-[[3eij]] - hCED-4 residues 157-469<BR />
-[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I
-===CED-5===
-[[1yyb]] - hCED-5 N terminal – NMR<BR />
-[[2cru]], [[2k6b]] - hCED-5 – NMR<BR />
-===CED-6===
-[[1y1x]] - CED-6 – ''Leishmania major''
-===CED-9===
-[[1ohu]] – CeCED-9 <BR />
-[[1ty4]] - CeCED-9 + programmed CED activator
-===CED-10===
-[[3ajm]] - hCED-10 + inositol tetrakisphosphate
-===CED-HAC-1===
-[[1vt4]], [[3iz8]] – CED-HAC-1 – ''Drosophila melanogaster''