Cadherin: Difference between revisions

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{{STRUCTURE_1q1p|  PDB=1q1p  | SIZE=400| SCENE=Cadherin/Cv/1 |right|CAPTION=Epithelial cadherin complex with Ca+2 ions, [[1q1p]] }}
<StructureSection load='2a4c' size='350' side='right' scene='41/417481/Cv/4' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'>
<StructureSection load='3lne' size='450' side='right' scene= caption='Lymnaea acetylcholine-binding protein pentamer complex with acetylcholine (PDB code 3wip)'>
__TOC__
== Function ==
== Function ==


[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental).  The CDH superfamily contains:<br /> *'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<br />
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney).  The CDH superfamily contains:<br />
*'''Desmogleins''' (Des-CDH) are CDH found in desmosomes.   
*'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
*'''Desmogleins''' (Des-CDH) and '''desmocollin''' are CDH found in desmosomes.   
 


== Structural highlights ==
== Structural highlights ==


The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''.
The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref>


== 3D Structures of Cadherin ==
== 3D Structures of Cadherin ==
[[Cadherin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
* CDH1
 
**[[1q1p]] – mCDH1 - mouse<br />
**[[3q2v]] – mCDH1 ectodomain<br />
**[[3qrb]] – mCDH1+2
 
* CDH5
 
**[[2koh]] – mCDH5+PAR3-PDZ3<br />
 
* CDH6
 
**[[3lnd]] – mCDH6 EC12 (mutant)<br />
 
* CDH8
 
**[[1zxk]] – mCDH8 EC1<br />
**[[2a62]] - mCDH8 EC1+EC2+EC3<br />
 
* CDH11
 
**[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
 
* CDH20
 
**[[1zvn]] – cCDH20 EC1 – chicken<br />
 
* CDH23
 
**[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
**[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
**[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
**[[2wbx]] – mCDH23 EC1<br />
**[[2wcp]] - mCDH23 EC2<br />
**[[2wd0]] - mCDH23 EC1+EC2 (mutant)<br />
**[[4apx]], [[4aq8]], [[4axw]] - mCDH23 EC1+EC2 + Prot-CDH15<br />
**[[4aqa]], [[4aqe]] - mCDH23 EC1+EC2 (mutant) + Prot-CDH15
 
* C-CDH “classical”
 
**[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
**[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
 
* E-CDH epithelial
 
**[[1edh]] - mE-CDH EC1+EC2+Ca<br />
**[[3q2l]], [[3q2n]] - mE-CDH EC1+EC2 (mutant)<br />
**[[1suh]] – mE-CDH N-terminal - NMR<br />
**[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
**[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
**[[2qvf]] – mE-CDH1 CDH2<br />
**[[4qd2]] – mE-CDH + botulinum neurotoxin<br />
**[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
**[[2o72]] - hE-CDH EC1+EC2<br />
**[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
**[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
**[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
 
* T-CDH membrane bound
 
**[[3k5r]] – mT-CDH EC1+EC2<br />
**[[3k5s]] - cT-CDH EC1+EC2 <br />
**[[3k6d]] - XlT-CDH EC1 <br />
**[[3k6f]] - mT-CDH EC1<br />
**[[3k6i]] - cT-CDH EC1<br />
**[[2v37]] – hT-CDH N-terminal - NMR<br />
 
* N-CDH neuronal
 
**[[1nch]], [[1nci]] – mN-CDH<br />
**[[1ncg]] – mN-CDH (mutant)<br />
**[[2qvi]], [[4nuq]] – mN-CDH EC1-EC2<br />
**[[4num]], [[4nup]] – mN-CDH EC1-EC2 (mutant)<br />
**[[1ncj]] – mN-CDH two domains<br />
**[[3q2w]] – mN-CDH ectodomain<br />
**[[1op4]] - mN-CDH prodomain - NMR<br />
**[[3ubf]] – DmN-CDH ectodomain – ''Drosophila melanogaster''<br />
**[[3ubh]] - DmN-CDH EC1-4<br />
**[[3ubg]] - DmN-CDH EC1-3
 
*P-CDH placental
 
**[[4nqq]] – mP-CDH EC1+EC2<br />
 
*VE-CDH vascular epithelial
 
**[[3ppe]] – cVE-CDH EC1+EC2<br />
 
* Protocadherin
 
**[[2yst]] – hProt-CDH7 EC3 – NMR<br />
**[[2ee0]] - hProt-CDH9 Ca domain – NMR<br />
**[[1wyj]] - mProt-CDH β 14 - NMR<br />
**[[1wuz]] - mProt-CDH4 EC1 – NMR
 
* Desmoglein


**[[2yqg]] – hDes-CDH EC1<br />
== References ==
}}
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:53, 2 June 2024

Function

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains:

  • Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.[1]
  • Desmogleins (Des-CDH) and desmocollin are CDH found in desmosomes.


Structural highlights

The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by docking into the hydrophobic pocket of the neighboring CDH molecule. [2]

3D Structures of Cadherin

Cadherin 3D structures


Mouse cadherin-11 EC1 dimer (PDB code 2a4c)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
  2. ↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

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Alexander Berchansky, Michal Harel
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