Cadherin: Difference between revisions

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[[Image:1q1p.png|left|200px|thumb|Crystal Structure of Cadherin, [[1q1p]]]]
<StructureSection load='2a4c' size='350' side='right' scene='41/417481/Cv/4' caption='Mouse cadherin-11 EC1 dimer (PDB code [[2a4c]])'>
{{STRUCTURE_1q1p|  PDB=1q1p  | SIZE=300| SCENE=Cadherin/Cv/1 |right|CAPTION=Cadherin, [[1q1p]] }}
__TOC__
== Function ==


[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: E-CDH (epithelial tissue), T-CDH bound to membrane, N-CDH (neurons).  The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, ''i.e.'' the crystal structure of Cadherin ([[1q1p]]).  Calcium ions is shown as a space filling objects.
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: '''E-CDH''' (epithelial tissue), '''VE-CDH''' (vascular epithelial), '''T-CDH''' bound to membrane, '''N-CDH''' (neurons), '''P-CDH''' (placental), '''K-CDH''' (kidney).  The CDH superfamily contains:<br />
*'''Protocadhedrins''' (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains.  They are found mainly in the brain at cell-cell contacts.<ref>PMID:11171368</ref> <br />
*'''Desmogleins''' (Des-CDH) and '''desmocollin''' are CDH found in desmosomes.  


{{TOC limit|limit=2}}


== 3D Structures of Cadherin ==
== Structural highlights ==


The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''. The strand swapping is enhanced by <scene name='41/417481/Cv/5'>2 Trp residues</scene> docking into the hydrophobic pocket of the neighboring CDH molecule. <ref>PMID:16564015</ref>


== 3D Structures of Cadherin ==
[[Cadherin 3D structures]]


</StructureSection>


=== CDH encoded by CDH1 ===
== References ==
 
<references/>
 
[[Category:Topic Page]]
[[1q1p]] – mCDH1 - mouse<br />
 
 
=== CDH encoded by CDH5 ===
 
 
[[2koh]] – mCDH5+PAR3-PDZ3<br />
 
 
=== CDH encoded by CDH6 ===
 
 
[[3lnd]] – mCDH6 EC12 (mutant)<br />
 
 
=== CDH encoded by CDH8 ===
 
 
[[1zxk]] – mCDH8 EC1<br />
[[2a62]] - mCDH8 EC1+EC2+EC3<br />
 
 
=== CDH encoded by CDH11 ===
 
 
[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
 
 
=== CDH encoded by CDH20 ===
 
 
[[1zvn]] – cCDH20 EC1 – chicken<br />
 
 
=== CDH encoded by CDH23 ===
 
 
[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />
[[2kbr]] – hCDH23 peptide+harmonin – NMR - human<br />
[[2kbs]] - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR<br />
[[2wbx]] – mCDH23 EC1<br />
[[2wcp]] - mCDH23 EC2<br />
[[2wd0]] - mCDH23 EC1+EC2 (mutant)
 
 
=== C-CDH “classical” ===
 
 
[[1l3w]] – XlC-CDH ectodomain - ''Xenopus laevis''<br />
[[1q5b]], [[1q5c]], [[1q55]], [[1q5a]] – C-CDH model into desmosome – electron tomography<br />
 
 
=== E-CDH epithelial ===
 
 
[[1ff5]] – mE-CDH double domain<br />
[[1edh]] - mE-CDH EC1+EC2+Ca<br />
[[1suh]] – mE-CDH N-terminal - NMR<br />
[[3l6x]], [[3l6y]], [[1i7x]], [[1i7w]] – mE-CDH+catenin<br />
[[3lne]], [[3lnf]], [[3lng]], [[3lnh]], [[3lni]] – mE-CDH EC12 (mutant)<br />
[[3ifq]] – hE-CDH EC1+EC2+EC3 <br />
[[2o72]] - hE-CDH EC1+EC2<br />
[[3ff7]], [[3ff8]] - hE-CDH EC1+EC2+EC3+NK cell receptor<br />
[[2qvf]] – mE-CDH1 CDH2<br />
[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
 
 
=== T-CDH membrane bound ===
 
 
[[3k5r]] – mT-CDH EC1+EC2<br />
[[3k5s]] - cT-CDH EC1+EC2 <br />
[[3k6d]] - XlT-CDH EC1 <br />
[[3k6f]] - mT-CDH EC1<br />
[[3k6i]] - cT-CDH EC1<br />
[[2v37]] – hT-CDH N-terminal - NMR<br />
 
 
=== N-CDH neuronal ===
 
 
[[1nch]], [[1nci]] – mN-CDH<br />
[[1ncg]] – mN-CDH (mutant)<br />
[[2qvi]] – mN-CDH EC12<br />
[[1ncj]] – mN-CDH two domains<br />
[[1op4]] - mN-CDH prodomain - NMR
 
=== Protocadherin ===
 
 
[[2yst]] – hProt-CDH7 EC3 – NMR<br />
[[2ee0]] - hProt-CDH9 Ca domain – NMR
[[1wyj]] - mProt-CDH β 14 - NMR
 
 
=== Desmoglein ===
 
 
[[2yqg]] – hDes-CDH EC1<br />

Latest revision as of 09:53, 2 June 2024

Function

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental), K-CDH (kidney). The CDH superfamily contains:

  • Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.[1]
  • Desmogleins (Des-CDH) and desmocollin are CDH found in desmosomes.


Structural highlights

The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by docking into the hydrophobic pocket of the neighboring CDH molecule. [2]

3D Structures of Cadherin

Cadherin 3D structures


Mouse cadherin-11 EC1 dimer (PDB code 2a4c)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001 Feb;114(Pt 4):629-41. PMID:11171368
  2. ↑ Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 doi:http://dx.doi.org/10.1016/j.cell.2005.12.046

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Alexander Berchansky, Michal Harel
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