1m7k: Difference between revisions

No edit summary
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Solution Structure of the SODD BAG Domain==
==Solution Structure of the SODD BAG Domain==
<StructureSection load='1m7k' size='340' side='right' caption='[[1m7k]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1m7k' size='340' side='right'caption='[[1m7k]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1m7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M7K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1m7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M7K FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m7k RCSB], [http://www.ebi.ac.uk/pdbsum/1m7k PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7k OCA], [https://pdbe.org/1m7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m7k RCSB], [https://www.ebi.ac.uk/pdbsum/1m7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m7k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BAG4_HUMAN BAG4_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.  
[https://www.uniprot.org/uniprot/BAG4_HUMAN BAG4_HUMAN] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/1m7k_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/1m7k_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m7k ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 25: Line 27:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1m7k" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[BAG protein|BAG protein]]
*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 33: Line 36:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brockmann, C]]
[[Category: Large Structures]]
[[Category: Buessow, K]]
[[Category: Brockmann C]]
[[Category: Diehl, A]]
[[Category: Buessow K]]
[[Category: Labudde, D]]
[[Category: Diehl A]]
[[Category: Leitner, D]]
[[Category: Labudde D]]
[[Category: Oschkinat, H]]
[[Category: Leitner D]]
[[Category: Sievert, V]]
[[Category: Oschkinat H]]
[[Category: Chaperone]]
[[Category: Sievert V]]
[[Category: Three helix bundle]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA