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[[Image:1ef5.jpg|left|200px]]


{{Structure
==SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL==
|PDB= 1ef5 |SIZE=350|CAPTION= <scene name='initialview01'>1ef5</scene>
<StructureSection load='1ef5' size='340' side='right'caption='[[1ef5]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1ef5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EF5 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ef5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ef5 OCA], [https://pdbe.org/1ef5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ef5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ef5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ef5 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ef5 TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL'''
[https://www.uniprot.org/uniprot/RGL1_MOUSE RGL1_MOUSE] Probable guanine nucleotide exchange factor.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/1ef5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ef5 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.


==About this Structure==
Solution structure of the Ras-binding domain of RGL.,Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:9891982<ref>PMID:9891982</ref>
1EF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EF5 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Solution structure of the Ras-binding domain of RGL., Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S, FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9891982 9891982]
</div>
<div class="pdbe-citations 1ef5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Endo M]]
[[Category: Endo, M.]]
[[Category: Ito Y]]
[[Category: Ito, Y.]]
[[Category: Kigawa T]]
[[Category: Kigawa, T.]]
[[Category: Kikuchi A]]
[[Category: Kikuchi, A.]]
[[Category: Shirouzu M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Shirouzu, M.]]
[[Category: Yokoyama, S.]]
[[Category: ra]]
[[Category: ra]]
[[Category: ras-binding domain]]
[[Category: rbd]]
[[Category: rgl]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
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