2-isopropylmalate synthase: Difference between revisions
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<StructureSection load='' size='400' side='right' caption='2-isopropylmalate synthase complex with leucine, glycerol and Zn+2 ion (grey) (PDB code [[3fig]])' scene='74/748866/Cv/1'> | <StructureSection load='' size='400' side='right' caption='2-isopropylmalate synthase complex with leucine, glycerol and Zn+2 ion (grey) (PDB code [[3fig]])' scene='74/748866/Cv/1'> | ||
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== Function == | == Function == | ||
'''2-isopropylmalate synthase''' (LeuA) or '''α-isopropylmalate synthase''' catalyzes the reversible conversion of 3-methyl-2-oxobutanoate and acetyl-CoA to 2-isopropylmalate. LeuA participates in the biosynthesis of leucine and pyruvate metabolism<ref>PMID:16846242</ref>. It is involved in the second step of the leucine biosynthetic pathway, catalyzing the formation of 2-isopropylmalate from acetyl-CoA and α-ketoisovalerate. | '''2-isopropylmalate synthase''' (LeuA) or '''α-isopropylmalate synthase''' catalyzes the reversible conversion of 3-methyl-2-oxobutanoate and acetyl-CoA to 2-isopropylmalate. LeuA participates in the biosynthesis of leucine and pyruvate metabolism<ref>PMID:16846242</ref>. It is involved in the second step of the leucine biosynthetic pathway, catalyzing the formation of 2-isopropylmalate from acetyl-CoA and α-ketoisovalerate. | ||