2lum: Difference between revisions
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==Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)== | ==Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)== | ||
<StructureSection load='2lum' size='340' side='right' caption='[[2lum | <StructureSection load='2lum' size='340' side='right'caption='[[2lum]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lum]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lum OCA], [https://pdbe.org/2lum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lum RCSB], [https://www.ebi.ac.uk/pdbsum/2lum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lum ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 2lum" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2lum" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Guntert | [[Category: Streptococcus sp. 'group G']] | ||
[[Category: Kazemi | [[Category: Guntert P]] | ||
[[Category: Riek | [[Category: Kazemi S]] | ||
[[Category: Vogeli | [[Category: Riek R]] | ||
[[Category: Vogeli B]] | |||
Latest revision as of 08:52, 15 May 2024
Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)
Structural highlights
FunctionPublication Abstract from PubMedProteins are inherently dynamic systems whose motions cover large ranges in both magnitude and timescale. Because of the omnipresence of motion, it is likely that dynamics have important roles in the function of biomolecules. For detailed understanding of a protein's function, the three-dimensional structure and description of its dynamics are therefore required. Structure determination methods are well established, and NMR-relaxation phenomena provide insights into local molecular dynamics; moreover, recently several attempts have been made to detect concerted motion. Here, we present an ensemble-based structure-determination protocol using ensemble-averaged distance restraints obtained from exact NOE rates. Application to the model protein GB3 establishes an ensemble of structures that reveals correlated motion across the beta-sheet, concerted motion between the backbone and side chains localized in the structure core, and a lack of concerted conformational exchange between the beta-sheet and the alpha-helix. Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs.,Vogeli B, Kazemi S, Guntert P, Riek R Nat Struct Mol Biol. 2012 Sep 2. doi: 10.1038/nsmb.2355. PMID:22940676[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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