2lum: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2lum.png|left|200px]]
-{{STRUCTURE_2lum|  PDB=2lum  |  SCENE=  }}
+==Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)==
+<StructureSection load='2lum' size='340' side='right'caption='[[2lum]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2lum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lum OCA], [https://pdbe.org/2lum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lum RCSB], [https://www.ebi.ac.uk/pdbsum/2lum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lum ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Proteins are inherently dynamic systems whose motions cover large ranges in both magnitude and timescale. Because of the omnipresence of motion, it is likely that dynamics have important roles in the function of biomolecules. For detailed understanding of a protein's function, the three-dimensional structure and description of its dynamics are therefore required. Structure determination methods are well established, and NMR-relaxation phenomena provide insights into local molecular dynamics; moreover, recently several attempts have been made to detect concerted motion. Here, we present an ensemble-based structure-determination protocol using ensemble-averaged distance restraints obtained from exact NOE rates. Application to the model protein GB3 establishes an ensemble of structures that reveals correlated motion across the beta-sheet, concerted motion between the backbone and side chains localized in the structure core, and a lack of concerted conformational exchange between the beta-sheet and the alpha-helix.
-===Three-State Ensemble obtained from eNOEs of the Third Immunoglobulin Binding Domain of Protein G (GB3)===
+Spatial elucidation of motion in proteins by ensemble-based structure calculation using exact NOEs.,Vogeli B, Kazemi S, Guntert P, Riek R Nat Struct Mol Biol. 2012 Sep 2. doi: 10.1038/nsmb.2355. PMID:22940676<ref>PMID:22940676</ref>
-{{ABSTRACT_PUBMED_22940676}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2lum" style="background-color:#fffaf0;"></div>
-[[2lum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUM OCA].
+== References ==
-[[Category: Bacteria]]
+<references/>
-[[Category: Guntert, P.]]
+__TOC__
-[[Category: Kazemi, S.]]
+</StructureSection>
-[[Category: Riek, R.]]
+[[Category: Large Structures]]
-[[Category: Vogeli, B.]]
+[[Category: Streptococcus sp. 'group G']]
-[[Category: Correlated dynamic]]
+[[Category: Guntert P]]
-[[Category: Enoe]]
+[[Category: Kazemi S]]
-[[Category: Exact nuclear overhauser effect]]
+[[Category: Riek R]]
-[[Category: Noe]]
+[[Category: Vogeli B]]
-[[Category: Protein binding]]
-[[Category: Structure calculation]]
-[[Category: Structure ensemble]]