2ckc: Difference between revisions
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==Solution structures of the BRK domains of the human Chromo Helicase Domain 7 and 8, reveals structural similarity with GYF domain suggesting a role in protein interaction== | ==Solution structures of the BRK domains of the human Chromo Helicase Domain 7 and 8, reveals structural similarity with GYF domain suggesting a role in protein interaction== | ||
<StructureSection load='2ckc' size='340' side='right' caption='[[2ckc | <StructureSection load='2ckc' size='340' side='right'caption='[[2ckc]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ckc]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ckc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ckc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckc OCA], [https://pdbe.org/2ckc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ckc RCSB], [https://www.ebi.ac.uk/pdbsum/2ckc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CHD7_HUMAN CHD7_HUMAN] CHARGE syndrome;Normosmic congenital hypogonadotropic hypogonadism;Omenn syndrome;Kallmann syndrome. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CHD7_HUMAN CHD7_HUMAN] Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.<ref>PMID:22646239</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Chromodomain-helicase-DNA-binding protein|Chromodomain-helicase-DNA-binding protein]] | *[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]] | ||
*[[Helicase|Helicase]] | *[[Helicase 3D structures|Helicase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Ab | [[Category: Large Structures]] | ||
[[Category: Daniels | [[Category: Ab E]] | ||
[[Category: Diercks | [[Category: Daniels M]] | ||
[[Category: Folkers | [[Category: Diercks T]] | ||
[[Category: Folkers GE]] | |||
[[Category: Kaptein | [[Category: Kaptein R]] | ||
[[Category: Xiaoyun | [[Category: Xiaoyun J]] | ||
[[Category: | [[Category: De Jong RN]] | ||