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==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
<StructureSection load='4uxt' size='340' side='right' caption='[[4uxt]], [[Resolution|resolution]] 7.40&Aring;' scene=''>
<SX load='4uxt' size='340' side='right' viewer='molstar' caption='[[4uxt]], [[Resolution|resolution]] 7.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uxt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uxo|4uxo]], [[4uxp|4uxp]], [[4uxr|4uxr]], [[4uxs|4uxs]], [[4uxy|4uxy]], [[4uy0|4uy0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxt OCA], [http://pdbe.org/4uxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uxt RCSB], [http://www.ebi.ac.uk/pdbsum/4uxt PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxt OCA], [https://pdbe.org/4uxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxt RCSB], [https://www.ebi.ac.uk/pdbsum/4uxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxt ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/KIF5A_HUMAN KIF5A_HUMAN]] Autosomal dominant spastic paraplegia type 10;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:12355402</ref> <ref>PMID:15452312</ref> <ref>PMID:16476820</ref> <ref>PMID:16489470</ref> <ref>PMID:18203753</ref> <ref>PMID:18245137</ref> <ref>PMID:18853458</ref> <ref>PMID:21107874</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF5A_HUMAN KIF5A_HUMAN]] Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).  
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Tubulin|Tubulin]]
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Atherton, J]]
[[Category: Homo sapiens]]
[[Category: Farabella, I]]
[[Category: Large Structures]]
[[Category: Houdusse, A]]
[[Category: Atherton J]]
[[Category: Moores, C]]
[[Category: Farabella I]]
[[Category: Rosenfeld, S S]]
[[Category: Houdusse A]]
[[Category: Topf, M]]
[[Category: Moores C]]
[[Category: Yu, I M]]
[[Category: Rosenfeld SS]]
[[Category: Transport protein]]
[[Category: Topf M]]
[[Category: Yu IM]]

Latest revision as of 14:24, 9 May 2024

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesinsConserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

4uxt, resolution 7.40Å

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