2x8a: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2x8a.png|left|200px]]
-{{STRUCTURE_2x8a|  PDB=2x8a  |  SCENE=  }}
+==Human Nuclear Valosin containing protein Like (NVL), C-terminal AAA- ATPase domain==
+<StructureSection load='2x8a' size='340' side='right'caption='[[2x8a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===HUMAN NUCLEAR VALOSIN CONTAINING PROTEIN LIKE (NVL), C-TERMINAL AAA-ATPASE DOMAIN===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2x8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8A FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[2x8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8A OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8a OCA], [https://pdbe.org/2x8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8a RCSB], [https://www.ebi.ac.uk/pdbsum/2x8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NVL_HUMAN NVL_HUMAN] Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).<ref>PMID:15469983</ref> <ref>PMID:16782053</ref> <ref>PMID:22226966</ref> <ref>PMID:26166824</ref> <ref>PMID:26456651</ref> <ref>PMID:28416111</ref> <ref>PMID:29107693</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8a ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Berglund, H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Berglund H]]
-[[Category: Collins, R.]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M.]]
+[[Category: Collins R]]
-[[Category: Flodin, S.]]
+[[Category: Edwards AM]]
-[[Category: Flores, A.]]
+[[Category: Flodin S]]
-[[Category: Graslund, S.]]
+[[Category: Flores A]]
-[[Category: Hammarstrom, M.]]
+[[Category: Graslund S]]
-[[Category: Johansson, I.]]
+[[Category: Hammarstrom M]]
-[[Category: Kallas, A.]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T.]]
+[[Category: Kallas A]]
-[[Category: Kotenyova, T.]]
+[[Category: Karlberg T]]
-[[Category: Kraulis, P.]]
+[[Category: Kotenyova T]]
-[[Category: Moche, M.]]
+[[Category: Kraulis P]]
-[[Category: Nordlund, P.]]
+[[Category: Moche M]]
-[[Category: Nyman, T.]]
+[[Category: Nordlund P]]
-[[Category: Persson, C.]]
+[[Category: Nyman T]]
-[[Category: Schuetz, P.]]
+[[Category: Persson C]]
-[[Category: Schuler, H.]]
+[[Category: Schuetz P]]
-[[Category: Sehic, A.]]
+[[Category: Schuler H]]
-[[Category: Siponen, M I.]]
+[[Category: Sehic A]]
-[[Category: Svensson, L.]]
+[[Category: Siponen MI]]
-[[Category: Thorsell, A G.]]
+[[Category: Svensson L]]
-[[Category: Tresaugues, L.]]
+[[Category: Thorsell AG]]
-[[Category: Vandenberg, S.]]
+[[Category: Tresaugues L]]
-[[Category: Wahlberg, E.]]
+[[Category: VanDenBerg S]]
-[[Category: Weigelt, J.]]
+[[Category: Wahlberg E]]
-[[Category: Welin, M.]]
+[[Category: Weigelt J]]
-[[Category: Wisniewska, M.]]
+[[Category: Welin M]]
-[[Category: Nuclear protein]]
+[[Category: Wisniewska M]]