2cf2: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2cf2.png|left|200px]]
-<!--
+==Architecture of mammalian fatty acid synthase==
-The line below this paragraph, containing "STRUCTURE_2cf2", creates the "Structure Box" on the page.
+<StructureSection load='2cf2' size='340' side='right'caption='[[2cf2]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2cf2]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The June 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CF2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cf2 OCA], [https://pdbe.org/2cf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2cf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cf2 ProSAT]</span></td></tr>
-{{STRUCTURE_2cf2|  PDB=2cf2  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cf2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cf2 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The homodimeric mammalian fatty acid synthase is one of the most complex cellular multienzymes, in that each 270-kilodalton polypeptide chain carries all seven functional domains required for fatty acid synthesis. We have calculated a 4.5 angstrom-resolution x-ray crystallographic map of porcine fatty acid synthase, highly homologous to the human multienzyme, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density. The positioning of domains reveals the complex architecture of the multienzyme forming an intertwined dimer with two lateral semicircular reaction chambers, each containing a full set of catalytic domains required for fatty acid elongation. Large distances between active sites and conformational differences between the reaction chambers demonstrate that mobility of the acyl carrier protein and general flexibility of the multienzyme must accompany handover of the reaction intermediates during the reaction cycle.
-===ARCHITECTURE OF MAMMALIAN FATTY ACID SYNTHASE===
+Architecture of mammalian fatty acid synthase at 4.5 A resolution.,Maier T, Jenni S, Ban N Science. 2006 Mar 3;311(5765):1258-62. PMID:16513975<ref>PMID:16513975</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2cf2" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16513975}}, adds the Publication Abstract to the page
+*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16513975 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16513975}}
+__TOC__
+</StructureSection>
-==About this Structure==
-CF2 is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The June 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Fatty Acid Synthase''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_6 10.2210/rcsb_pdb/mom_2007_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CF2 OCA].
-==Reference==
-<ref group="xtra">PMID:16513975</ref><references group="xtra"/>
 [[Category: Fatty Acid Synthase]]
-[[Category: Fatty-acid synthase]]
+[[Category: Large Structures]]
+[[Category: RCSB PDB Molecule of the Month]]
 [[Category: Sus scrofa]]
-[[Category: Ban, N.]]
+[[Category: Ban N]]
-[[Category: Jenni, S.]]
+[[Category: Jenni S]]
-[[Category: Maier, T.]]
+[[Category: Maier T]]
-[[Category: Fatty acid biosynthesis]]
-[[Category: Fatty acid metabolism]]
-[[Category: Multienzyme]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:54:21 2009''