1suv: Difference between revisions

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[[Image:1suv.png|left|200px]]


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==Structure of Human Transferrin Receptor-Transferrin Complex==
The line below this paragraph, containing "STRUCTURE_1suv", creates the "Structure Box" on the page.
<SX load='1suv' size='340' side='right' viewer='molstar' caption='[[1suv]], [[Resolution|resolution]] 7.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1suv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SUV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
{{STRUCTURE_1suv| PDB=1suv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1suv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1suv OCA], [https://pdbe.org/1suv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1suv RCSB], [https://www.ebi.ac.uk/pdbsum/1suv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1suv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TFR1_HUMAN TFR1_HUMAN] Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.<ref>PMID:3568132</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1suv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1suv ConSurf].
<div style="clear:both"></div>


===Structure of Human Transferrin Receptor-Transferrin Complex===
==See Also==
 
*[[Transferrin 3D structures|Transferrin 3D structures]]
 
*[[Transferrin receptor|Transferrin receptor]]
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== References ==
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{{ABSTRACT_PUBMED_14980223}}
 
==Disease==
Known disease associated with this structure: Atransferrinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190000 190000]], Iron deficiency anemia, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190000 190000]]
 
==About this Structure==
1SUV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUV OCA].
 
==Reference==
Structure of the human transferrin receptor-transferrin complex., Cheng Y, Zak O, Aisen P, Harrison SC, Walz T, Cell. 2004 Feb 20;116(4):565-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14980223 14980223]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Aisen, P.]]
[[Category: Aisen P]]
[[Category: Cheng, Y.]]
[[Category: Cheng Y]]
[[Category: Harrison, S C.]]
[[Category: Harrison SC]]
[[Category: Walz, T.]]
[[Category: Walz T]]
[[Category: Zak, O.]]
[[Category: Zak O]]
[[Category: Protein complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:46:28 2008''

Latest revision as of 11:35, 1 May 2024

Structure of Human Transferrin Receptor-Transferrin ComplexStructure of Human Transferrin Receptor-Transferrin Complex

1suv, resolution 7.50Å

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