1slv: Difference between revisions

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[[Image:1slv.png|left|200px]]


{{STRUCTURE_1slv|  PDB=1slv  |  SCENE=  }}
==RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUND==
 
<StructureSection load='1slv' size='340' side='right'caption='[[1slv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUND===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1slv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SLV FirstGlance]. <br>
{{ABSTRACT_PUBMED_8634241}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1slv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1slv OCA], [https://pdbe.org/1slv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1slv RCSB], [https://www.ebi.ac.uk/pdbsum/1slv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1slv ProSAT]</span></td></tr>
[[1slv]] is a 2 chain structure of [[Ecotin]] and [[Trypsin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SLV OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ECOT_ECOLI ECOT_ECOLI] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sl/1slv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1slv ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ecotin|Ecotin]]
*[[Ecotin|Ecotin]]
*[[Trypsin|Trypsin]]
*[[Trypsin 3D structures|Trypsin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:008634241</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Trypsin]]
[[Category: Brinen LS]]
[[Category: Brinen, L S.]]
[[Category: Fletterick RJ]]
[[Category: Fletterick, R J.]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Metal binding site]]
[[Category: Metalloprotein]]
[[Category: Protease-substrate interaction]]
[[Category: Protein engineering]]
[[Category: Serine protease]]

Latest revision as of 11:33, 1 May 2024

RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUNDRAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUND

Structural highlights

1slv is a 2 chain structure with sequence from Escherichia coli and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ECOT_ECOLI General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1slv, resolution 2.30Å

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