1sf2: Difference between revisions

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[[Image:1sf2.png|left|200px]]


{{STRUCTURE_1sf2| PDB=1sf2 | SCENE= }}
==Structure of E. coli gamma-aminobutyrate aminotransferase==
<StructureSection load='1sf2' size='340' side='right'caption='[[1sf2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1sf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SF2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sf2 OCA], [https://pdbe.org/1sf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sf2 RCSB], [https://www.ebi.ac.uk/pdbsum/1sf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sf2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GABT_ECOLI GABT_ECOLI] Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA).<ref>PMID:20639325</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sf/1sf2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sf2 ConSurf].
<div style="clear:both"></div>


===Structure of E. coli gamma-aminobutyrate aminotransferase===
==See Also==
 
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
{{ABSTRACT_PUBMED_15323550}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1sf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SF2 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:015323550</ref><ref group="xtra">PMID:016754985</ref><ref group="xtra">PMID:019146406</ref><references group="xtra"/>
[[Category: 4-aminobutyrate transaminase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Carter, R J.]]
[[Category: Large Structures]]
[[Category: Fisher, A J.]]
[[Category: Carter RJ]]
[[Category: Langston, J A.]]
[[Category: Fisher AJ]]
[[Category: Liu, W.]]
[[Category: Langston JA]]
[[Category: Peterson, P E.]]
[[Category: Liu W]]
[[Category: Toney, M D.]]
[[Category: Peterson PE]]
[[Category: Zhou, X.]]
[[Category: Toney MD]]
[[Category: Aminotransferase]]
[[Category: Zhou X]]
[[Category: Transferase]]

Latest revision as of 11:31, 1 May 2024

Structure of E. coli gamma-aminobutyrate aminotransferaseStructure of E. coli gamma-aminobutyrate aminotransferase

Structural highlights

1sf2 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GABT_ECOLI Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kurihara S, Kato K, Asada K, Kumagai H, Suzuki H. A putrescine-inducible pathway comprising PuuE-YneI in which gamma-aminobutyrate is degraded into succinate in Escherichia coli K-12. J Bacteriol. 2010 Sep;192(18):4582-91. doi: 10.1128/JB.00308-10. Epub 2010 Jul, 16. PMID:20639325 doi:http://dx.doi.org/10.1128/JB.00308-10

1sf2, resolution 2.40Å

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