7r4l: Difference between revisions
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==Crystal structure of human mitochondrial NAD kinase== | ==Crystal structure of human mitochondrial NAD kinase== | ||
<StructureSection load='7r4l' size='340' side='right'caption='[[7r4l]]' scene=''> | <StructureSection load='7r4l' size='340' side='right'caption='[[7r4l]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4L FirstGlance]. <br> | <table><tr><td colspan='2'>[[7r4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4L FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4l OCA], [https://pdbe.org/7r4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4l RCSB], [https://www.ebi.ac.uk/pdbsum/7r4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4l ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4l OCA], [https://pdbe.org/7r4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4l RCSB], [https://www.ebi.ac.uk/pdbsum/7r4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4l ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Progressive encephalopathy with leukodystrophy due to DECR deficiency. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NAKD2_HUMAN NAKD2_HUMAN] Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.<ref>PMID:23212377</ref> | |||
==See Also== | |||
*[[NAD kinase|NAD kinase]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gelin M]] | [[Category: Gelin M]] | ||
Latest revision as of 10:54, 1 May 2024
Crystal structure of human mitochondrial NAD kinaseCrystal structure of human mitochondrial NAD kinase
Structural highlights
DiseaseNAKD2_HUMAN Progressive encephalopathy with leukodystrophy due to DECR deficiency. The disease is caused by variants affecting the gene represented in this entry. FunctionNAKD2_HUMAN Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo.[1] See AlsoReferences
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