6mg9: Difference between revisions

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'''Unreleased structure'''


The entry 6mg9 is ON HOLD
==Human Obscurin Ig57 Domain==
<StructureSection load='6mg9' size='340' side='right'caption='[[6mg9]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MG9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg9 OCA], [https://pdbe.org/6mg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mg9 RCSB], [https://www.ebi.ac.uk/pdbsum/6mg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OBSCN_HUMAN OBSCN_HUMAN] Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:11448995</ref> <ref>PMID:16205939</ref>


Authors: Wright, N.T., Whitley, J.A.
==See Also==
 
*[[Obscurin|Obscurin]]
Description: Human Obscurin Ig57
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Wright, N.T]]
__TOC__
[[Category: Whitley, J.A]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Whitley JA]]
[[Category: Wright NT]]

Latest revision as of 10:36, 1 May 2024

Human Obscurin Ig57 DomainHuman Obscurin Ig57 Domain

Structural highlights

6mg9 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OBSCN_HUMAN Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.[1] [2]

See Also

References

  1. ↑ Young P, Ehler E, Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol. 2001 Jul 9;154(1):123-36. PMID:11448995
  2. ↑ Borisov AB, Sutter SB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW. Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem Cell Biol. 2006 Mar;125(3):227-38. Epub 2005 Oct 5. PMID:16205939 doi:http://dx.doi.org/10.1007/s00418-005-0069-x
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