5uke: Difference between revisions
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New page: '''Unreleased structure''' The entry 5uke is ON HOLD Authors: Description: Category: Unreleased Structures |
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==NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant== | |||
<StructureSection load='5uke' size='340' side='right'caption='[[5uke]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5uke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UKE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uke OCA], [https://pdbe.org/5uke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uke RCSB], [https://www.ebi.ac.uk/pdbsum/5uke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uke ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IRAK3_HUMAN IRAK3_HUMAN] Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2]<ref>PMID:10383454</ref> | |||
==See Also== | |||
*[[Interleukin-1 receptor-associated kinase|Interleukin-1 receptor-associated kinase]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kwon J]] | |||
[[Category: Nicholson LK]] | |||
Latest revision as of 10:28, 1 May 2024
NMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutantNMR structure of monomeric human IRAK-M Death Domain R56D, Y61E mutant
Structural highlights
DiseaseIRAK3_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. FunctionIRAK3_HUMAN Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.[UniProtKB:Q8K4B2][1] See AlsoReferences |
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