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[[Image:2j5b.jpg|left|200px]]<br /><applet load="2j5b" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2j5b, resolution 2.20&Aring;" />
'''STRUCTURE OF THE TYROSYL TRNA SYNTHETASE FROM ACANTHAMOEBA POLYPHAGA MIMIVIRUS COMPLEXED WITH TYROSYNOL'''<br />


==About this Structure==
==Structure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed with tyrosynol==
2J5B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus] with <scene name='pdbligand=TYB:'>TYB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] Known structural/functional Site: <scene name='pdbsite=AC1:Tyb Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5B OCA].
<StructureSection load='2j5b' size='340' side='right'caption='[[2j5b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
[[Category: Mimivirus]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2j5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_polyphaga_mimivirus Acanthamoeba polyphaga mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5B FirstGlance]. <br>
[[Category: Tyrosine--tRNA ligase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Abergel, C.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYE:4-[(2S)-2-AMINO-3-HYDROXYPROPYL]PHENOL'>TYE</scene></td></tr>
[[Category: Claverie, J.M.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5b OCA], [https://pdbe.org/2j5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5b RCSB], [https://www.ebi.ac.uk/pdbsum/2j5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5b ProSAT]</span></td></tr>
[[Category: Giege, R.]]
</table>
[[Category: Rudinger-Thirion, J.]]
== Function ==
[[Category: TYB]]
[https://www.uniprot.org/uniprot/SYY_MIMIV SYY_MIMIV] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).<ref>PMID:15486256</ref> <ref>PMID:16510997</ref>
[[Category: ligase]]
== Evolutionary Conservation ==
[[Category: mimivirus]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: tyrosyl trna synthetase]]
Check<jmol>
[[Category: tyrosynol]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j5b ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:26:30 2008''
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acanthamoeba polyphaga mimivirus]]
[[Category: Large Structures]]
[[Category: Abergel C]]
[[Category: Claverie JM]]
[[Category: Giege R]]
[[Category: Rudinger-thirion J]]

Latest revision as of 09:41, 1 May 2024

Structure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed with tyrosynolStructure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed with tyrosynol

Structural highlights

2j5b is a 2 chain structure with sequence from Acanthamoeba polyphaga mimivirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SYY_MIMIV Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Raoult D, Audic S, Robert C, Abergel C, Renesto P, Ogata H, La Scola B, Suzan M, Claverie JM. The 1.2-megabase genome sequence of Mimivirus. Science. 2004 Nov 19;306(5700):1344-50. Epub 2004 Oct 14. PMID:15486256 doi:http://dx.doi.org/1101485
  2. ↑ Abergel C, Chenivesse S, Byrne D, Suhre K, Arondel V, Claverie JM. Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt, 2):212-5. Epub 2005 Jan 20. PMID:16510997 doi:10.1107/S174430910500062X

2j5b, resolution 2.20Å

Drag the structure with the mouse to rotate

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