2dk4: Difference between revisions

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[[Image:2dk4.gif|left|200px]]


{{Structure
==Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)==
|PDB= 2dk4 |SIZE=350|CAPTION= <scene name='initialview01'>2dk4</scene>
<StructureSection load='2dk4' size='340' side='right'caption='[[2dk4]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dk4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DK4 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= PRPF18, HPRP18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dk4 OCA], [https://pdbe.org/2dk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2dk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dk4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dk4 TOPSAN]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRP18_HUMAN PRP18_HUMAN] Participates in the second step of pre-mRNA splicing.<ref>PMID:9000057</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dk4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dk4 ConSurf].
<div style="clear:both"></div>


'''Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)'''
==See Also==
 
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
 
== References ==
==About this Structure==
<references/>
2DK4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DK4 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: He, F.]]
[[Category: He F]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: hprp18]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nmr]]
[[Category: nppsfa]]
[[Category: pre-mrna splicing factor 18]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: sfm domain]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:28:10 2008''

Latest revision as of 09:39, 1 May 2024

Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)Solution structure of Splicing Factor Motif in Pre-mRNA splicing factor 18 (hPRP18)

Structural highlights

2dk4 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PRP18_HUMAN Participates in the second step of pre-mRNA splicing.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Horowitz DS, Krainer AR. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes Dev. 1997 Jan 1;11(1):139-51. PMID:9000057
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OCA
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