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==THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA== | ==THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA== | ||
<StructureSection load='1nhm' size='340' side='right'caption='[[1nhm | <StructureSection load='1nhm' size='340' side='right'caption='[[1nhm]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1nhm]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1nhm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NHM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nhm OCA], [https://pdbe.org/1nhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nhm RCSB], [https://www.ebi.ac.uk/pdbsum/1nhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nhm ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HMGB1_CRIGR HMGB1_CRIGR] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Cricetulus griseus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carillo | [[Category: Carillo MOM]] | ||
[[Category: Cary | [[Category: Cary PD]] | ||
[[Category: Crane-Robinson | [[Category: Crane-Robinson C]] | ||
[[Category: Driscoll | [[Category: Driscoll PC]] | ||
[[Category: Norman | [[Category: Norman DG]] | ||
[[Category: Read | [[Category: Read CM]] | ||
Latest revision as of 11:49, 10 April 2024
THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNATHE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA
Structural highlights
FunctionHMGB1_CRIGR DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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