1ls5: Difference between revisions

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[[Image:1ls5.png|left|200px]]


{{STRUCTURE_1ls5|  PDB=1ls5  |  SCENE=  }}
==Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A==
 
<StructureSection load='1ls5' size='340' side='right'caption='[[1ls5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ls5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jgf 1jgf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LS5 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12614616}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ls5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ls5 OCA], [https://pdbe.org/1ls5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ls5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ls5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ls5 ProSAT]</span></td></tr>
[[1ls5]] is a 4 chain structure of [[Plasmepsin]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jgf 1jgf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS5 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLM4_PLAF7 PLM4_PLAF7] During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:Q17SB3]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1ls5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ls5 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Plasmepsin|Plasmepsin]]
*[[Plasmepsin|Plasmepsin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012614616</ref><ref group="xtra">PMID:016939205</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Afonina, E.]]
[[Category: Streptomyces argenteolus subsp. toyonakensis]]
[[Category: Asojo, O A.]]
[[Category: Afonina E]]
[[Category: Ellman, J A.]]
[[Category: Asojo OA]]
[[Category: Gulnik, S V.]]
[[Category: Ellman JA]]
[[Category: Haque, T S.]]
[[Category: Gulnik SV]]
[[Category: Silva, A M.]]
[[Category: Haque TS]]
[[Category: Yu, B.]]
[[Category: Silva AM]]
[[Category: Eukaryotic aspartic proteinase]]
[[Category: Yu B]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Latest revision as of 11:27, 10 April 2024

Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin ACrystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A

Structural highlights

1ls5 is a 4 chain structure with sequence from Plasmodium falciparum and Streptomyces argenteolus subsp. toyonakensis. This structure supersedes the now removed PDB entry 1jgf. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PLM4_PLAF7 During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:Q17SB3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ls5, resolution 2.80Å

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