1jpl: Difference between revisions

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-[[Image:1jpl.png|left|200px]]
-{{STRUCTURE_1jpl|  PDB=1jpl  |  SCENE=  }}
+==GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor==
+<StructureSection load='1jpl' size='340' side='right'caption='[[1jpl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1jpl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPL FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11859375}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpl OCA], [https://pdbe.org/1jpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpl RCSB], [https://www.ebi.ac.uk/pdbsum/1jpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpl ProSAT]</span></td></tr>
-[[1jpl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPL OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
-<ref group="xtra">PMID:011859375</ref><references group="xtra"/>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/1jpl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jpl ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bonifacino, J S.]]
+[[Category: Large Structures]]
-[[Category: Hurley, J H.]]
+[[Category: Bonifacino JS]]
-[[Category: Misra, S.]]
+[[Category: Hurley JH]]
-[[Category: Puertollano, R.]]
+[[Category: Misra S]]
-[[Category: Dxxll sorting signal]]
+[[Category: Puertollano R]]
-[[Category: Protein-peptide complex]]
-[[Category: Signaling protein]]
-[[Category: Vhs domain]]