1jpl

GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptorGGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Structural highlights

1jpl is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MPRI_HUMAN Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8439-44. PMID:10900005

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OCA

[1] Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8439-44. PMID:10900005

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1jpl

GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptorGGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Structural highlights

Function

Evolutionary Conservation

References

Contents

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1jpl

GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptorGGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Structural highlights

Function

Evolutionary Conservation

References

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