1gk5: Difference between revisions

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[[Image:1gk5.gif|left|200px]]


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==Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor==
The line below this paragraph, containing "STRUCTURE_1gk5", creates the "Structure Box" on the page.
<StructureSection load='1gk5' size='340' side='right'caption='[[1gk5]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1gk5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GK5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gk5 OCA], [https://pdbe.org/1gk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gk5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gk5 ProSAT]</span></td></tr>
{{STRUCTURE_1gk5| PDB=1gk5 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/EGF_MOUSE EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gk5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gk5 ConSurf].
<div style="clear:both"></div>


'''SOLUTION STRUCTURE THE MEGF/TGFALPHA44-50 CHIMERIC GROWTH FACTOR'''
==See Also==
 
*[[Epidermal growth factor|Epidermal growth factor]]
 
__TOC__
==Overview==
</StructureSection>
The solution structure of the growth factor chimera mEGF/TGFalpha44-50 has been determined using an extended version of the dyana procedure for calculating structures from NMR data. The backbone fold and preferred orientation of the domains of the chimera are similar to those found in previous studies of EGF structures, and several H-bonds used as input constraints in those studies were found independently in the chimera. This shows that the modified activity of the chimera does not result from a major structural change. However, the improved precision of the structure presented here allows the origin of some unusual chemical shifts found in all of these compounds to be explained, as well as the results obtained from some site-specific mutants. Further studies of the properties of this chimeric growth factor should help to elucidate the mechanism(s) of hetero- and homodimerization of the c-erbB receptors.
[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
==About this Structure==
1GK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA].
 
==Reference==
Solution structure of the mEGF/TGFalpha44-50 chimeric growth factor., Chamberlin SG, Brennan L, Puddicombe SM, Davies DE, Turner DL, Eur J Biochem. 2001 Dec;268(23):6247-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11733021 11733021]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Brennan L]]
[[Category: Brennan, L.]]
[[Category: Chamberlin SG]]
[[Category: Chamberlin, S G.]]
[[Category: Davies DE]]
[[Category: Davies, D E.]]
[[Category: Puddicombe SM]]
[[Category: Puddicombe, S M.]]
[[Category: Turner DL]]
[[Category: Turner, D L.]]
[[Category: Chimeric]]
[[Category: Egf growth factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:40:44 2008''

Latest revision as of 14:22, 27 March 2024

Solution Structure the mEGF/TGFalpha44-50 chimeric growth factorSolution Structure the mEGF/TGFalpha44-50 chimeric growth factor

Structural highlights

1gk5 is a 1 chain structure with sequence from Homo sapiens and Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EGF_MOUSE EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).TGFA_HUMAN TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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