1gk5: Difference between revisions
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==Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor== | |||
<StructureSection load='1gk5' size='340' side='right'caption='[[1gk5]]' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gk5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GK5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gk5 OCA], [https://pdbe.org/1gk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gk5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gk5 ProSAT]</span></td></tr> | |||
== | </table> | ||
[[1gk5]] is a 1 chain structure | == Function == | ||
[https://www.uniprot.org/uniprot/EGF_MOUSE EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gk5_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gk5 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Epidermal growth factor|Epidermal growth factor]] | *[[Epidermal growth factor|Epidermal growth factor]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Brennan | [[Category: Brennan L]] | ||
[[Category: Chamberlin | [[Category: Chamberlin SG]] | ||
[[Category: Davies | [[Category: Davies DE]] | ||
[[Category: Puddicombe | [[Category: Puddicombe SM]] | ||
[[Category: Turner | [[Category: Turner DL]] | ||
Latest revision as of 14:22, 27 March 2024
Solution Structure the mEGF/TGFalpha44-50 chimeric growth factorSolution Structure the mEGF/TGFalpha44-50 chimeric growth factor
Structural highlights
FunctionEGF_MOUSE EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).TGFA_HUMAN TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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