6kn7: Difference between revisions
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The entry | ==Structure of human cardiac thin filament in the calcium free state== | ||
<SX load='6kn7' size='340' side='right' viewer='molstar' caption='[[6kn7]], [[Resolution|resolution]] 6.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6kn7]] is a 29 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn7 OCA], [https://pdbe.org/6kn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn7 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn7 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TPM1_HUMAN TPM1_HUMAN] Left ventricular noncompaction;Familial isolated hypertrophic cardiomyopathy;Familial isolated dilated cardiomyopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TPM1_HUMAN TPM1_HUMAN] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | |||
==See Also== | |||
*[[Actin 3D structures|Actin 3D structures]] | |||
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]] | |||
[[Category: | *[[Troponin 3D structures|Troponin 3D structures]] | ||
__TOC__ | |||
</SX> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Fujii T]] | |||
[[Category: Namba K]] | |||
[[Category: Yamada Y]] | |||
Latest revision as of 13:43, 27 March 2024
Structure of human cardiac thin filament in the calcium free stateStructure of human cardiac thin filament in the calcium free state
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