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<StructureSection load='6ixn' size='340' side='right'caption='[[6ixn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='6ixn' size='340' side='right'caption='[[6ixn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ixn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IXN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ixn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ostreococcus_tauri Ostreococcus tauri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IXN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixn OCA], [http://pdbe.org/6ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ixn RCSB], [http://www.ebi.ac.uk/pdbsum/6ixn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixn ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ixn OCA], [https://pdbe.org/6ixn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ixn RCSB], [https://www.ebi.ac.uk/pdbsum/6ixn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ixn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDH_OSTTA IDH_OSTTA] Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (Probable). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production (Probable).<ref>PMID:25724193</ref>
==See Also==
*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Tang, W G]]
[[Category: Ostreococcus tauri]]
[[Category: Wang, P]]
[[Category: Tang WG]]
[[Category: Zhu, G P]]
[[Category: Wang P]]
[[Category: Isocitrate dehydrogenase]]
[[Category: Zhu GP]]
[[Category: Oxidoreductase]]

Latest revision as of 13:35, 27 March 2024

Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and citrateCrystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with NAD+ and citrate

Structural highlights

6ixn is a 4 chain structure with sequence from Ostreococcus tauri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.87Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IDH_OSTTA Performs an essential role in the oxidative function of the tricarboxylic acid cycle and respiration (Probable). Catalyzes the decarboxylation of isocitrate to produce 2-oxoglutarate and generate NADH to provide electrons for energy production (Probable).[1]

See Also

References

  1. ↑ Tang WG, Song P, Cao ZY, Wang P, Zhu GP. A unique homodimeric NAD(+)-linked isocitrate dehydrogenase from the smallest autotrophic eukaryote Ostreococcus tauri. FASEB J. 2015 Jun;29(6):2462-72. doi: 10.1096/fj.14-257014. Epub 2015 Feb 27. PMID:25724193 doi:http://dx.doi.org/10.1096/fj.14-257014

6ixn, resolution 1.87Å

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