5yiy: Difference between revisions

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-'''Unreleased structure'''
-The entry 5yiy is ON HOLD  until Paper Publication
+==Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis==
+<StructureSection load='5yiy' size='340' side='right'caption='[[5yiy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Karade, S.S., Pratap, J.V.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yiy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YIY FirstGlance]. <br>
-Description: Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Pratap, J.V]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yiy OCA], [https://pdbe.org/5yiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yiy RCSB], [https://www.ebi.ac.uk/pdbsum/5yiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yiy ProSAT]</span></td></tr>
-[[Category: Karade, S.S]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COATR_MYCTU COATR_MYCTU] Probably involved in fatty acid metabolism. Binds to fatty acyl-CoAs of varying carbon chain lengths, with the highest binding affinity for palmitoyl-CoA (C16:0). In vitro, alters the cell wall lipid profile and protects mycobacteria from acidic, oxidative and antibiotic stress. May play a significant role in host-pathogen interaction.<ref>PMID:30342240</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Karade SS]]
+[[Category: Pratap JV]]