5yiy

Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosisCrystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis

Structural highlights

5yiy is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.504Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COATR_MYCTU Probably involved in fatty acid metabolism. Binds to fatty acyl-CoAs of varying carbon chain lengths, with the highest binding affinity for palmitoyl-CoA (C16:0). In vitro, alters the cell wall lipid profile and protects mycobacteria from acidic, oxidative and antibiotic stress. May play a significant role in host-pathogen interaction.^[1]

References

↑ Karade SS, Pandey S, Ansari A, Das S, Tripathi S, Arora A, Chopra S, Pratap JV, Dasgupta A. Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress. Biochim Biophys Acta Proteins Proteom. 2018 Oct 17. pii: S1570-9639(18)30180-8., doi: 10.1016/j.bbapap.2018.10.011. PMID:30342240 doi:http://dx.doi.org/10.1016/j.bbapap.2018.10.011

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OCA

[1] Karade SS, Pandey S, Ansari A, Das S, Tripathi S, Arora A, Chopra S, Pratap JV, Dasgupta A. Rv3272 encodes a novel Family III CoA transferase that alters the cell wall lipid profile and protects mycobacteria from acidic and oxidative stress. Biochim Biophys Acta Proteins Proteom. 2018 Oct 17. pii: S1570-9639(18)30180-8., doi: 10.1016/j.bbapap.2018.10.011. PMID:30342240 doi:http://dx.doi.org/10.1016/j.bbapap.2018.10.011

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