4hmw: Difference between revisions
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==Crystal structure of PhzG from Burkholderia lata 383== | |||
<StructureSection load='4hmw' size='340' side='right'caption='[[4hmw]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hmw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_lata Burkholderia lata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HMW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hmw OCA], [https://pdbe.org/4hmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hmw RCSB], [https://www.ebi.ac.uk/pdbsum/4hmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hmw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHZG_BURL3 PHZG_BURL3] Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control (PubMed:23897464). Catalyzes several oxidations in the terminal steps of core phenazine biosynthesis. It oxidizes both hexahydrophenazine-1,6-dicarboxylic acid (HHPDC) and tetrahydrophenazine-1-carboxylic acid (THPCA) and thereby contributes to the generation of both phenazine-1,6-dicarboxylic acid (PDC) and phenazine-1-carboxylic acid (PCA). It synthesizes phenazines in their reduced form, which are the likely end products in vivo (PubMed:23897464).<ref>PMID:23897464</ref> | |||
==See Also== | |||
*[[Pyridoxine 5'-phosphate oxidase|Pyridoxine 5'-phosphate oxidase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Burkholderia lata]] | |||
[[Category: Large Structures]] | |||
[[Category: Ahuja EG]] | |||
[[Category: Blankenfeldt W]] | |||
[[Category: Xu NN]] | |||
Latest revision as of 11:52, 20 March 2024
Crystal structure of PhzG from Burkholderia lata 383Crystal structure of PhzG from Burkholderia lata 383
Structural highlights
FunctionPHZG_BURL3 Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control (PubMed:23897464). Catalyzes several oxidations in the terminal steps of core phenazine biosynthesis. It oxidizes both hexahydrophenazine-1,6-dicarboxylic acid (HHPDC) and tetrahydrophenazine-1-carboxylic acid (THPCA) and thereby contributes to the generation of both phenazine-1,6-dicarboxylic acid (PDC) and phenazine-1-carboxylic acid (PCA). It synthesizes phenazines in their reduced form, which are the likely end products in vivo (PubMed:23897464).[1] See AlsoReferences
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