4e2s: Difference between revisions

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==Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine==
The line below this paragraph, containing "STRUCTURE_4e2s", creates the "Structure Box" on the page.
<StructureSection load='4e2s' size='340' side='right'caption='[[4e2s]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4e2s]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E2S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UGY:(2S)-AMINO(CARBAMOYLAMINO)ETHANOIC+ACID'>UGY</scene></td></tr>
{{STRUCTURE_4e2s|  PDB=4e2s  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2s OCA], [https://pdbe.org/4e2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e2s RCSB], [https://www.ebi.ac.uk/pdbsum/4e2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2s ProSAT]</span></td></tr>
 
</table>
===Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine===
== Function ==
 
[https://www.uniprot.org/uniprot/UGHY_ARATH UGHY_ARATH] Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.<ref>PMID:19935661</ref> <ref>PMID:20038185</ref> <ref>PMID:22493446</ref>
 
== References ==
==About this Structure==
<references/>
[[4e2s]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2S OCA].  
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Rhee, S.]]
[[Category: Large Structures]]
[[Category: Shin, I.]]
[[Category: Rhee S]]
[[Category: Bi-cupin]]
[[Category: Shin I]]
[[Category: Endoplasmic reticulumn]]
[[Category: Hydrolase]]
[[Category: Manganese binding]]

Latest revision as of 11:49, 20 March 2024

Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-UreidoglycineCrystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine

Structural highlights

4e2s is a 16 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.59Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UGHY_ARATH Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.[1] [2] [3]

References

  1. ↑ Werner AK, Romeis T, Witte CP. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat Chem Biol. 2010 Jan;6(1):19-21. Epub 2009 Nov 22. PMID:19935661 doi:http://dx.doi.org/nchembio.265
  2. ↑ Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem Biol. 2010 Feb 19;5(2):203-14. doi: 10.1021/cb900248n. PMID:20038185 doi:http://dx.doi.org/10.1021/cb900248n
  3. ↑ Shin I, Percudani R, Rhee S. Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. J Biol Chem. 2012 May 25;287(22):18796-805. Epub 2012 Apr 5. PMID:22493446 doi:10.1074/jbc.M111.331819

4e2s, resolution 2.59Å

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