4e2s

Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-UreidoglycineCrystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine

Structural highlights

4e2s is a 16 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.59Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UGHY_ARATH Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.^[1] ^[2] ^[3]

References

↑ Werner AK, Romeis T, Witte CP. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat Chem Biol. 2010 Jan;6(1):19-21. Epub 2009 Nov 22. PMID:19935661 doi:http://dx.doi.org/nchembio.265
↑ Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem Biol. 2010 Feb 19;5(2):203-14. doi: 10.1021/cb900248n. PMID:20038185 doi:http://dx.doi.org/10.1021/cb900248n
↑ Shin I, Percudani R, Rhee S. Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. J Biol Chem. 2012 May 25;287(22):18796-805. Epub 2012 Apr 5. PMID:22493446 doi:10.1074/jbc.M111.331819

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OCA

[1] Werner AK, Romeis T, Witte CP. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat Chem Biol. 2010 Jan;6(1):19-21. Epub 2009 Nov 22. PMID:19935661 doi:http://dx.doi.org/nchembio.265

[2] Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem Biol. 2010 Feb 19;5(2):203-14. doi: 10.1021/cb900248n. PMID:20038185 doi:http://dx.doi.org/10.1021/cb900248n

[3] Shin I, Percudani R, Rhee S. Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. J Biol Chem. 2012 May 25;287(22):18796-805. Epub 2012 Apr 5. PMID:22493446 doi:10.1074/jbc.M111.331819

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[2]

[3]

4e2s

Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-UreidoglycineCrystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine

Structural highlights

Function

References

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4e2s

Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-UreidoglycineCrystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine

Structural highlights

Function

References

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