4e2s: Difference between revisions
New page: '''Unreleased structure''' The entry 4e2s is ON HOLD Authors: Shin, I., Rhee, S. Description: Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex... |
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==Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine== | |||
<StructureSection load='4e2s' size='340' side='right'caption='[[4e2s]], [[Resolution|resolution]] 2.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4e2s]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E2S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UGY:(2S)-AMINO(CARBAMOYLAMINO)ETHANOIC+ACID'>UGY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e2s OCA], [https://pdbe.org/4e2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e2s RCSB], [https://www.ebi.ac.uk/pdbsum/4e2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e2s ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UGHY_ARATH UGHY_ARATH] Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.<ref>PMID:19935661</ref> <ref>PMID:20038185</ref> <ref>PMID:22493446</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Rhee S]] | |||
[[Category: Shin I]] | |||