3ter: Difference between revisions
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== | ==Crystal structure of SOAR domain with Inhibition helix from C. elegans== | ||
[[3ter]] is a 2 chain structure with sequence from [ | <StructureSection load='3ter' size='340' side='right'caption='[[3ter]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[3ter]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TER FirstGlance]. <br> | ||
< | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ter FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ter OCA], [https://pdbe.org/3ter PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ter RCSB], [https://www.ebi.ac.uk/pdbsum/3ter PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ter ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/STIM1_CAEEL STIM1_CAEEL] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemeostasis.<ref>PMID:16966474</ref> <ref>PMID:17218360</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Cai | [[Category: Large Structures]] | ||
[[Category: Jin | [[Category: Cai X]] | ||
[[Category: Shen | [[Category: Jin H]] | ||
[[Category: Yang | [[Category: Shen Y]] | ||
[[Category: Yang X]] | |||