3isp: Difference between revisions

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-{{STRUCTURE_3isp|  PDB=3isp  |  SCENE=  }}
-===Crystal structure of ArgP from Mycobacterium tuberculosis===
-{{ABSTRACT_PUBMED_20036253}}
-==About this Structure==
+==Crystal structure of ArgP from Mycobacterium tuberculosis==
-[[3isp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA].
+<StructureSection load='3isp' size='340' side='right'caption='[[3isp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
-==Reference==
+<table><tr><td colspan='2'>[[3isp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ISP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ISP FirstGlance]. <br>
-<ref group="xtra">PMID:020036253</ref><references group="xtra"/><references/>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-[[Category: Mycobacterium tuberculosis]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3isp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3isp OCA], [https://pdbe.org/3isp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3isp RCSB], [https://www.ebi.ac.uk/pdbsum/3isp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3isp ProSAT]</span></td></tr>
-[[Category: Bartlam, M.]]
+</table>
-[[Category: Lou, Z.]]
+== Function ==
-[[Category: Rao, Z.]]
+[https://www.uniprot.org/uniprot/LYSG_MYCTU LYSG_MYCTU] Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a coinducer, lysine or histidine. Acts by binding to lysG-lysE promoter region. Also up-regulates the expression of ppsB, ppsC and ppsD, by binding to the upstream region of ppsB.<ref>PMID:29049397</ref>
-[[Category: Sheng, F.]]
+== Evolutionary Conservation ==
-[[Category: Wang, H.]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: Zhou, X.]]
+Check<jmol>
-[[Category: Dna binding domain]]
+  <jmolCheckbox>
-[[Category: Dna-binding]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/3isp_consurf.spt"</scriptWhenChecked>
-[[Category: Regulatory domain]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Rod shaped structure]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Transcription]]
+  </jmolCheckbox>
-[[Category: Transcription regulation]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3isp ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Bartlam M]]
+[[Category: Lou Z]]
+[[Category: Rao Z]]
+[[Category: Sheng F]]
+[[Category: Wang H]]
+[[Category: Zhou X]]