4evv: Difference between revisions
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==mouse MBD4 glycosylase domain in complex with a G:T mismatch== | |||
<StructureSection load='4evv' size='340' side='right'caption='[[4evv]], [[Resolution|resolution]] 2.39Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4evv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EVV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4evv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4evv OCA], [https://pdbe.org/4evv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4evv RCSB], [https://www.ebi.ac.uk/pdbsum/4evv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4evv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. | |||
== | ==See Also== | ||
*[[Methyl CpG binding protein|Methyl CpG binding protein]] | |||
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | [[Category: Large Structures]] | ||
< | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Cheng | [[Category: Cheng X]] | ||
[[Category: Hashimoto | [[Category: Hashimoto H]] | ||
[[Category: Zhang | [[Category: Zhang X]] | ||
Latest revision as of 18:10, 14 March 2024
mouse MBD4 glycosylase domain in complex with a G:T mismatchmouse MBD4 glycosylase domain in complex with a G:T mismatch
Structural highlights
FunctionMBD4_MOUSE Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. See Also |
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