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==Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)==
==Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)==
<StructureSection load='3v7o' size='340' side='right' caption='[[3v7o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3v7o' size='340' side='right'caption='[[3v7o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. <br>
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston_(1989) Reston ebolavirus - Reston (1989)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V7O FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [https://pdbe.org/3v7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [https://www.ebi.ac.uk/pdbsum/3v7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7o ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [http://www.ebi.ac.uk/pdbsum/3v7o PDBsum]</span></td></tr>
</table>
<table>
== Function ==
<div style="background-color:#fffaf0;">
[https://www.uniprot.org/uniprot/VP30_EBORR VP30_EBORR] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).
== Publication Abstract from PubMed ==
The ebolaviruses can cause severe hemorrhagic fever. Essential to the ebolavirus life cycle is the protein VP30, which serves as a transcriptional cofactor. Here, the crystal structure of the C-terminal, NP-binding domain of VP30 from Reston ebolavirus is presented. Reston VP30 and Ebola VP30 both form homodimers, but the dimeric interfaces are rotated relative to each other, suggesting subtle inherent differences or flexibility in the dimeric interface.
 
Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eborr]]
[[Category: Large Structures]]
[[Category: Disease, Seattle Structural Genomics Center for Infectious.]]
[[Category: Structural genomic]]
[[Category: Ebola]]
[[Category: Nucleoprotein]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Smt]]
[[Category: Ssgcid]]
[[Category: Transcription]]
[[Category: Vp30]]

Latest revision as of 17:20, 14 March 2024

Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)

Structural highlights

3v7o is a 2 chain structure with sequence from Reston ebolavirus - Reston (1989). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VP30_EBORR Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).

See Also

3v7o, resolution 2.25Å

Drag the structure with the mouse to rotate

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