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==Crystal structure of the Phosphofructokinase-2 mutant Y23D from Escherichia coli==
==Crystal structure of the Phosphofructokinase-2 mutant Y23D from Escherichia coli==
<StructureSection load='3uqe' size='340' side='right' caption='[[3uqe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3uqe' size='340' side='right'caption='[[3uqe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uqe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UQE FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UQE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cqd|3cqd]], [[3n1c|3n1c]], [[3uqd|3uqd]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1723, JW5280, PFK2, pfkB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqe OCA], [https://pdbe.org/3uqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uqe RCSB], [https://www.ebi.ac.uk/pdbsum/3uqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqe ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uqe RCSB], [http://www.ebi.ac.uk/pdbsum/3uqe PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PFKB_ECOLI PFKB_ECOLI] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.<ref>PMID:16866375</ref>


==See Also==
==See Also==
*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 6-phosphofructokinase]]
[[Category: Escherichia coli K-12]]
[[Category: Escherichia coli k-12]]
[[Category: Large Structures]]
[[Category: Babul, J]]
[[Category: Babul J]]
[[Category: Baez, M]]
[[Category: Baez M]]
[[Category: Cabrera, R]]
[[Category: Cabrera R]]
[[Category: Caniuguir, A]]
[[Category: Caniuguir A]]
[[Category: Garatt, R C]]
[[Category: Garatt RC]]
[[Category: Pereira, H M]]
[[Category: Pereira HM]]
[[Category: Glycolysis]]
[[Category: Pfk-2]]
[[Category: Phosphofructokinase]]
[[Category: Transferase]]

Latest revision as of 17:06, 14 March 2024

Crystal structure of the Phosphofructokinase-2 mutant Y23D from Escherichia coliCrystal structure of the Phosphofructokinase-2 mutant Y23D from Escherichia coli

Structural highlights

3uqe is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PFKB_ECOLI Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[1]

See Also

References

  1. ↑ Parducci RE, Cabrera R, Baez M, Guixé V. Evidence for a catalytic Mg2+ ion and effect of phosphate on the activity of Escherichia coli phosphofructokinase-2: regulatory properties of a ribokinase family member. Biochemistry. 2006 Aug 1;45(30):9291-9. PMID:16866375 doi:10.1021/bi060026o

3uqe, resolution 2.20Å

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