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==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70==
==Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70==
<StructureSection load='3sy1' size='340' side='right' caption='[[3sy1]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
<StructureSection load='3sy1' size='340' side='right'caption='[[3sy1]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sy1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SY1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SY1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sy1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SY1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.465&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w8g|1w8g]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yggS, b2951, JW2918 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sy1 OCA], [https://pdbe.org/3sy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sy1 RCSB], [https://www.ebi.ac.uk/pdbsum/3sy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sy1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sy1 OCA], [http://pdbe.org/3sy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sy1 RCSB], [http://www.ebi.ac.uk/pdbsum/3sy1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sy1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLPHP_ECOLI PLPHP_ECOLI] Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins (PubMed:26872910). Does not have amino acid racemase activity (PubMed:24097949).<ref>PMID:24097949</ref> <ref>PMID:26872910</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Acton, T B]]
[[Category: Large Structures]]
[[Category: Baker, D]]
[[Category: Acton TB]]
[[Category: Ciccosanti, C]]
[[Category: Baker D]]
[[Category: Everett, J K]]
[[Category: Ciccosanti C]]
[[Category: Hunt, J F]]
[[Category: Everett JK]]
[[Category: Maglaqui, M]]
[[Category: Hunt JF]]
[[Category: Montelione, G T]]
[[Category: Maglaqui M]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Nair, R]]
[[Category: Nair R]]
[[Category: Nivon, L]]
[[Category: Nivon L]]
[[Category: Rost, B]]
[[Category: Rost B]]
[[Category: Sahdev, S]]
[[Category: Sahdev S]]
[[Category: Seetharaman, J]]
[[Category: Seetharaman J]]
[[Category: Su, M]]
[[Category: Su M]]
[[Category: Tong, L]]
[[Category: Tong L]]
[[Category: Vorobiev, S]]
[[Category: Vorobiev S]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Engineered protein]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Pyridoxal phosphate binding]]

Latest revision as of 16:11, 14 March 2024

Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70

Structural highlights

3sy1 is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.465Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PLPHP_ECOLI Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins (PubMed:26872910). Does not have amino acid racemase activity (PubMed:24097949).[1] [2]

References

  1. ↑ Ito T, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. Conserved pyridoxal protein that regulates Ile and Val metabolism. J Bacteriol. 2013 Dec;195(24):5439-49. PMID:24097949 doi:10.1128/JB.00593-13
  2. ↑ Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, El Badawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V. Evidence that COG0325 proteins are involved in PLP homeostasis. Microbiology (Reading). 2016 Apr;162(4):694-706. PMID:26872910 doi:10.1099/mic.0.000255

3sy1, resolution 1.47Å

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