3sy1

Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR70

Structural highlights

3sy1 is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.465Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PLPHP_ECOLI Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins (PubMed:26872910). Does not have amino acid racemase activity (PubMed:24097949).^[1] ^[2]

References

↑ Ito T, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. Conserved pyridoxal protein that regulates Ile and Val metabolism. J Bacteriol. 2013 Dec;195(24):5439-49. PMID:24097949 doi:10.1128/JB.00593-13
↑ Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, El Badawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V. Evidence that COG0325 proteins are involved in PLP homeostasis. Microbiology (Reading). 2016 Apr;162(4):694-706. PMID:26872910 doi:10.1099/mic.0.000255

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Ito T, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T. Conserved pyridoxal protein that regulates Ile and Val metabolism. J Bacteriol. 2013 Dec;195(24):5439-49. PMID:24097949 doi:10.1128/JB.00593-13

[2] Prunetti L, El Yacoubi B, Schiavon CR, Kirkpatrick E, Huang L, Bailly M, El Badawi-Sidhu M, Harrison K, Gregory JF, Fiehn O, Hanson AD, de Crécy-Lagard V. Evidence that COG0325 proteins are involved in PLP homeostasis. Microbiology (Reading). 2016 Apr;162(4):694-706. PMID:26872910 doi:10.1099/mic.0.000255

[1]

[2]